From an article in Newsmax by Ken Timmerman (read it all here): 

When newly appointed Prime Minister Benjamin Netanyahu meets with President Barack Obama next month, don’t expect a public spat over peace process politics. Sources in the new government tell Newsmax that the Israeli prime minister is determined to focus all of his energy on convincing Obama that preventing Iran from obtaining nuclear weapons dwarfs all other concerns either nation could have. Netanyahu sees the threat from a nuclear-armed Iran as a “hinge of history,” that could fundamentally alter the world if it goes unchallenged, sources told Newsmax in Jerusalem on Tuesday. 

If the world fails to meet the challenge of stopping the Iranian regime’s nuclear quest, Netanayhu believes “this could be a turning point that is irreversible.”

Should Iran succeed in acquiring nuclear weapons, it would be the first time that a radical Islamic regime dedicated to Israel’s destruction had ever acquired such massive destructive power. “We cannot assume that the normal rational calculations other actors have had for the last 50 or 60 years are going to hold true,” one source said.

But what if Obama desires that irreversible historical change? What if he desires Israel’s destruction? Every appointment he has made in connection with Middle East policy, every step he has taken since coming to power in relation to the Arabs and Islam, has demonstrated his sympathy with the Islamic powers – even to the point of inventing a ‘moderate Taliban’. His decision to base his Israel-Palestine policy on the Saudi plan, which is a formula for the destruction of Israel, confirms his lack of sympathy for the Jewish State. We suspect that Netanyahu is extremely unlikely to change Obama’s mind. There may or may not be a public spat specifically over the (misnamed) ‘peace process’, but there is very likely to be an irreconcilable clash over Iran.